Effects of succinates on the inflammatory response: a review

INTRODUCTION: Endogenous succinate functions as a pro-inflammatory factor, while exogenous — an anti-inflammatory factor. The mechanisms of effect succinates on the inflammatory response are not fully understood. OBJECTIVE: Generalization current scientific knowledge use in inhibition response. MATERIALS AND METHODS: PubMed, Web Science, Google Scholar, Scopus, and eLibrary international databases were used to search for relevant articles. keywords were: “succinic acid”, “amber “inflammation”, “meglumine sodium/solution”. was limited articles published between 2012 December 2022. inclusion criteria 1) research focused cellular energy supply inflammation; 2) effects intensity due changes supply; 3) correlation with clinical laboratory indicators when succinate-containing drugs used; 4) original studies. RESULTS: initial identification analysis included over 200 After screening, 84 full-text meeting selection final review: 31 literature reviews, 24 which dedicated endogenous succinate, 7 agents; 53 articles: 27 molecular 26 study drugs. CONCLUSIONS: is defined most important Exogenous has pronounced mediated by normalization immune cell hypoxia. No studies have been found differences mechanism action succinate.